Our Science
Restoring synaptic function to reverse cognitive decline.
Synaptic Repair Approach
EngramBio is built on the evidence that synapse dysfunction is an early and reversible driver of cognitive decline in Alzheimer's disease and related dementias. Currently, there are no approved therapeutics that directly repair synapses. Rather than targeting aggregated proteins associated with disease, our approach focuses on restoring synaptic function and increasing brain resilience to neurodegeneration.
KIBRA-Derived Therapeutics
EngramBio's lead program is based on KIBRA, a synaptic protein essential for learning and memory. Our KIBRA-derived peptide has been shown to repair synaptic plasticity, reverse synapse loss, and reverse memory deficits in disease-relevant models. We evaluate therapeutic efficacy using human iPSC-derived neurons, electrophysiology, and behavioral studies in mouse models.
Advancing Synapse Repair
By integrating rigorous mechanistic biology with AI-guided drug optimization and clinically relevant biomarkers that reflect synapse health and function, EngramBio is advancing a new class of synapse repair therapeutics. These treatments will be designed to preserve memory and improve outcomes for patients experiencing memory loss.
AI-Guided Peptide Engineering
Therapeutic peptides can engage targets that small molecules can't reach and offer biologic-like specificity, but their clinical translation is hard: native peptides are degraded in minutes by brain peptidases, and most AI structure-prediction tools cannot model the chemistry needed to make them stable. EngramBio closes that gap with a chemistry-aware AI workflow paired with physics-based simulation. Our pipeline iterates across thousands of candidate modifications, ranking each by binding-mode preservation, predicted brain stability, and drug-like properties. Promising candidates are confirmed under physics-based molecular dynamics and free-energy calculations, then handed off to wet-lab arbitration. Every in silico claim we make is paired with an experimental gold standard.
EngramBio
Reversing neurodegeneration through experimental biology and modern computation.
Location
Moraga, CA
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