Repair, restore, remember
Restoring memory formation to preserve quality of life
Through human-relevant biology and AI innovation, we are focused on repairing synapses to restore cognitive function and help patients remember what matters most.
Bridging Neuroscience and AI Innovation
At EngramBio, we combine neuroscience expertise with artificial intelligence to reimagine how therapies for neurodegenerative diseases are discovered and developed. Our discovery approach is built around human-relevant biology. By integrating human iPSC-derived neurons with advanced machine learning and computational biology, we create systems that more accurately reflect disease mechanisms in the human brain and better predict therapeutic success. Focused on repairing synapses rather than managing downstream pathology, we aim to restore cognitive function for people with dementia. We believe memory loss is not inevitable, and that reversing cognitive decline can become a reality.
Our Core Technology platform
Our integrated approach combines neuroscience with advanced computational tools to support discovery and therapeutic development.
In Silico Optimization & Target Prioritization
We use in silico screening and modeling to optimize lead molecules and prioritize synapse-repair targets identified from human data, published literature, and open-source databases.
Neuroscience-Led Wet Lab Validation
Lead candidates are validated and refined in rigorous wet-lab assays by our neuroscience team using disease-relevant models. We assess mechanism, synaptic function, and early translational signals to ensure biological rigor before advancing programs.
Diversified Synapse Repair Pipeline
A diversified synapse-repair pipeline supported by screening in diverse human neuronal models, enabling identification of therapies that restore synaptic function across patient-relevant contexts.
NIH NIA Startup Challenge Finalist
Selected as a finalist among top innovators nationwide for developing breakthrough technologies to advance healthy aging and address critical challenges in aging research.
NIH NIA Startup Challenge Winner
Awarded winner by the National Institute on Aging for our innovative approach to improving healthy aging outcomes, recognizing our technology's potential to transform aging care and research.
NVIDIA Inception
NVIDIA Inception is a program for early-stage startups that are using AI to solve real-world problems.
Leadership Team
Kristeen A. Pareja-Navarro, PhD
Chief Executive Officer, Founder
Dr. Pareja-Navarro is the CEO and co-founder of EngramBio, where she leads the development of therapeutics designed to r...
Ready to Transform Drug Discovery?
Join us in accelerating the development of life-changing neurological therapeutics.
Whether you're a pharmaceutical partner, investor, or research collaborator, let's discuss how we can work together to bring hope to patients worldwide.
Get in touch