Bridging Neuroscience and AI Innovation

At EngramBio, we engineer the next generation of therapeutics for neurodegenerative diseases by pairing deep neuroscience with a discipline-driven AI workflow. Our approach is anchored in human iPSC-derived neurons and other disease-relevant models. Our computational tools combine structure prediction and physics-based simulation to optimize candidates across binding, brain stability, and drug-like properties simultaneously. Every in silico claim is held against wet-lab arbitration, so what we advance into the clinic is what survives both rigorous computation and the experimental gold standard. We focus on repairing synapses rather than chasing downstream pathology, because we believe memory loss is not inevitable and reversing cognitive decline can become a reality.